I don't think nuzlocke comics should take themselves too seriously.
from what I've seen it doesn't work out much most of the time. I think its because of one main factor; the second you realize this is basically a pokemon fanfiction, it sorta falls apart; not to mention how most nuzlocke comics...
there's a lot of annoying things in nuzlocke; crits, statuses, missing important moves; but which one annoys you the most?
for me personally, wobuffets; they almost always take a pokemon from you, especially if you don't have something that chips their health gradually like toxic or will-o-wisp